PNC-27

PNC-27 is often referred to as the anticancer peptide as it contains an HDM-2-binding domain that corresponds to resides 12-26 of p53, as well as a transmembrane-penetrating domain that kills cancer cells by inducing membranolysis. Current research has found that the peptide can successfully induce tumor cell necrosis in both solid and non-solid tissues dependent on the expression of HDM-2 and selective transmembrane pore formation.

Main Research Findings

1) PNC-27 has the potential to induce tumor cell necrosis of a non-solid, tissue human leukemia cell line dependent on the expression of HDM-2 throughout the plasma membrane of tumor cells.

2) The peptide PNC-27 successfully binds to HDM-2 resulting in the induction of selective membrane-pore formation and cancer cell lysis.

PNC-27 is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses.